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Israeli experts say the artificial sweeteners may affect the human body sugar metabolism
According to U.S. media reported Thursday, researchers reported, artificial sweeteners may interfere with the body's ability to control blood sugar, lead to metabolic changes can be regarded as a precursor to diabetes.
In the discussion of the discovery news conference, Israel's Weizmann Institute of scientific research, the Weizmann Institute of Science) of immunologists elam, eli, Dr (Eran Elinav), said that "just happens to be our" when using a sweetener instead of sugar "usually want to avoid that situation".
Scientists in predominantly mice as experimental subjects were a large number of experiments, in order to support their conclusion: sweeteners will change the microbial flora in the digestive system.
The researchers point out that different flora composition changes of glucose metabolism, cause postprandial blood glucose levels rise even higher, falling speed is slower.
Eli's husband collaborators in Israel, including the weizmann institute of computer science and applied mathematics professor elam, Galveston (Eran Segal,).Their findings, published in the on Wednesday (17) published in the journal Nature (Nature).
Professor of pathology at the University of Chicago, University of Chicago) Catherine R, he (Cathryn r. Nagler), who was not involved in the study, but related commentary in the journal nature, said their findings "very convincing".
She points out that many symptoms, including obesity and diabetes has been thought is associated with the change of the microbial flora."This study shows that we should step back and reassess our widespread use of artificial sweeteners," she said.
Previous studies of the health effects of artificial sweeteners, come to the conclusion that the contradictory and confusing.Some studies reckon that sweetener is associated with weight loss;Others are just the opposite, found that people who drink diet soda actual heavier.
There are also some research concluded that artificial sweeteners and diabetes are related.But the conclusion is not credible: those who give up sugar, sweeteners and consumption products might already overweight, easy to suffer from diabetes.
In the preliminary experiments, the scientists hid saccharin (pink packaging fiber but joy [Sweet N 'Low] sweetener), sucralose (yellow packaging good goods sugar [Splenda] sweetener) or aspartame (blue packaging's mouth (Equal) sweetener) added to drinking water, let the intake of mice.Other mice, drink water, or add the glucose, or sugar water.A week later, the mice drinking water or sugar water change is not big, but the intake of the group that artificial sweeteners is apparent in the mice with glucose intolerance.
Glucose intolerance that reduce the body's ability to process large amounts of sugar, may cause more serious disease, such as the metabolic syndrome and type 2 diabetes.
When the researchers use of antibiotics in mice, kill many bacteria in the digestive system after their glucose intolerance problem disappears.
At present, scientists cannot explain how sweeteners affect these bacteria, and why in the process of glucose metabolism, saccharin, aspartame and sucralose these three different molecules leads to similar changes.
Scientists assume that changes in glucose metabolism is caused by the change of the bacteria, in order to further test this hypothesis, they carried out and a series of experiments for saccharin.Scientists from the saccharin water intake of mice intestinal bacteria, injected into mice never contact any saccharin.Then these mice have appeared in the glucose intolerance.DNA sequencing showed that the intake of saccharin in the intestines of mice and saccharin significantly changed the combination of bacterial species.
Next, the researchers began to track the nutrition and intestinal bacteria long-term health effects to the human body.The study is made up of 381 nondiabetic patients, the researchers found that the intake of any a kind of artificial sweeteners, and there is a correlation between glucose intolerance signs.In addition, is there any intake artificially sweetened, intestinal bacteria would be different.
Finally, the researchers recruited seven volunteers usually do not use artificial sweeteners, and in six days, to let them eat the American Food and Drug Administration, the Food and Drug Administration, FDA) suggested saccharin biggest intake.Results there are four people in seven of the blood sugar levels appeared with a similar change in mice.In addition, when the human subjects of bacteria in the intestines of injected into mice, the mice again glucose intolerance, this indicates that the effect is the same in mice and humans.
"I think this experiment is very convincing," said Dr Glenn.
Interestingly, "let us think both shocked and interesting," said Dr Siegel, appear this kind of effect, different from their gut bacteria without it.This suggests that any effect of artificial sweeteners are not universal.This suggests that probiotics -- containing the live bacteria drugs - can be used to change of bacteria in the intestine, to reverse glucose intolerance.
Harvard School of Public Health, Harvard School of Public Health, nutrition and immunology professor Dr Frank, Frank Hu Hu, who was not involved in the study, he says the study is very interesting, but is far from on this conclusion, because the number of subjects is not enough, he said, "I think the human studies the correctness of the problem."
Researchers said, the future project of aspartame, cross-linked with sugarcane, and other sweeteners such as stevia detailed research.
